Non-viral COVID-19 vaccine delivery systems

Non-Viral Delivery Systems in Gene Therapy and Vaccine Development

Gene therapy is the process of treating a particular disease through the introduction of genetic material in order to elicit a therapeutic benefit [Stone, 2010]. The defective gene of a diagnosed patient can be corrected by a number of different strategies such as “gene replacement”, “gene correction”, and “gene augmentation” [Katare and Aeri, 2010]. In replacement therapy, a normal gene is ins...

Non-Viral Delivery Systems in Gene Therapy

Recent advances in molecular biology combined with the culmination of the Human Ge‐ nome Project [1] have provided a genetic understanding of cellular processes and disease pathogenesis; numerous genes involved in disease and cellular processes have been identi‐ fied as targets for therapeutic approaches. In addition, the development of high-throughput screening techniques (e.g., cDNA microarra...

Ethical Issues in COVID-19 Vaccine Rollout

From the beginning of the COVID-19 pandemic, researchers aspired to produce an effective vaccine with appropriate efficacy and low side effects to mitigate the pandemic. It seems that vaccination is the only mean to save the world from this pandemic. In this article, we will review the ethical challenges of mass vaccination (focusing on the vaccine distribution and uptake), referring to the mai...

Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems

Hydroxychloroquine: A bridge prophylaxis till finding the COVID-19 vaccine

Regarding the importance of COVID-19 pandemic and risks that the infection imposes on healthcare workers, this manuscript discusses the potential usage of Hydroxychloroquine as a prophylactic agent.